Venki Ramakrishnan 30th Ulam Lecture Night 1 Ramakrishnan will provide a history of molecular visualization, as well as take us through his work at the MRC Laboratory of Molecular Biology in Cambridge, England, where his team determined the atomic structure of the 30S ribosomal subunit and its complexes with ligands and antibiotics. Everyone is familiar with DNA, but by itself, DNA is just an inert blueprint for life. It is the ribosome — an enormous molecular machine made up of a million atoms — that makes DNA come to life, turning our genetic code into proteins and therefore into us. He will talk about the ribosome (the “Gene Machine”), and how his team learned about its structure. He will also share some recent developments, including the development of cryoEM — a powerful technique used to determine the structure of three-dimensional structure of biological molecules at near-atomic resolution.

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