Kyu Hyong Park, Felipe Xavier Costa, Luis M. Rocha, Réka Albert, and Jordan C. Rozum

PRX Life 1, 023009 – Published 15 December 2023

Complex living systems are thought to exist at the “edge of chaos” separating the ordered dynamics of robust function from the disordered dynamics of rapid environmental adaptation. Here, a deeper inspection of 72 experimentally supported discrete dynamical models of cell processes reveals previously unobserved order on long time scales, suggesting greater rigidity in these systems than was previously conjectured. We find that propagation of internal perturbations is transient in most cases, and that even when large perturbation cascades persist, their phenotypic effects are often minimal. Moreover, we find evidence that stochasticity and desynchronization can lead to increased recovery from regulatory perturbation cascades. Our analysis relies on new measures that quantify the tendency of perturbations to spread through a discrete dynamical system. Computing these measures was not feasible using current methodology; thus, we developed a multipurpose CUDA-based simulation tool, which we have made available as the open-source Python library cubewalkers. Based on novel measures and simulations, our results suggest that—contrary to current theory—cell processes are ordered and far from the edge of chaos.

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Carlos Navarrete, Mariana Macedo, Rachael Colley, Jingling Zhang, Nicole Ferrada, Maria Eduarda Mello, Rodrigo Lira, Carmelo Bastos-Filho, Umberto Grandi, Jérôme Lang & César A. Hidalgo 

Nature Human Behaviour (2023)

Digital technologies can augment civic participation by facilitating the expression of detailed political preferences. Yet, digital participation efforts often rely on methods optimized for elections involving a few candidates. Here we present data collected in an online experiment where participants built personalized government programmes by combining policies proposed by the candidates of the 2022 French and Brazilian presidential elections. We use this data to explore aggregates complementing those used in social choice theory, finding that a metric of divisiveness, which is uncorrelated with traditional aggregation functions, can identify polarizing proposals. These metrics provide a score for the divisiveness of each proposal that can be estimated in the absence of data on the demographic characteristics of participants and that explains the issues that divide a population. These findings suggest that divisiveness metrics can be useful complements to traditional aggregation functions in direct forms of digital participation.

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KISHORE VASAN, DEISY MORSELLI GYSI, ALBERT-LÁSZLÓ BARABÁSI

iScience 26, 108361

The depth of knowledge offered by post-genomic medicine has carried the promise of new drugs, and cures for multiple diseases. To explore the degree to which this capability has materialized, we extract meta-data from 356,403 clinical trials spanning four decades, aiming to offer mechanistic insights into the innovation practices in drug discovery. We find that convention dominates over innovation, as over 96% of the recorded trials focus on previously tested drug targets, and the tested drugs target only 12% of the human interactome. If current patterns persist, it would take 170 years to target all druggable proteins. We uncover two network-based fundamental mechanisms that currently limit target discovery: preferential attachment, leading to the repeated exploration of previously targeted proteins; and local network effects, limiting exploration to proteins interacting with highly explored proteins. We build on these insights to develop a quantitative network-based model to enhance drug discovery in clinical trials.

Read the full article at: www.cell.com

Berry Gerrits, Wouter van Heeswijk, Martijn Mes

Intl. Trans. in Op. Res. 0 (2023) 1–66

Deploying self-organizing systems is a way to cope with the logistics sector’s complex, dynamic, and stochastic nature. In such systems, automated decision-making and decentralized or distributed control structures are combined. Such control structures reduce the complexity of decision-making, require less computational effort, and are therefore faster, reducing the risk that changes during decision-making render the solution invalid. These benefits of self-organizing systems are of interest to many practitioners involved in solving real-world problems in the logistics sector. This study, therefore, identifies and classifies research related to self-organizing logistics (SOL) with a focus on transportation. SOL is an interdisciplinary study across many domains and relates to other concepts, such as agent-based systems, autonomous control, and decentral systems. Yet, few papers directly identify this as self-organization. Hence, we add to the existing literature by conducting a systematic literature review that provides insight into the field of SOL. The main contribution of this paper is two-fold: (i) based on the findings from the literature review, we identify and synthesize 15 characteristics of SOL in a typology, and (ii) we present a two-dimensional SOL framework alongside the axes of autonomy and cooperativity to position and contrast the broad range of literature, thereby creating order in the field of SOL and revealing promising research directions.

Read the full article at: onlinelibrary.wiley.com

Philip Ball

Scientists worry that ill-informed use of artificial intelligence is driving a deluge of unreliable or useless research.

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