Julyan H. E. Cartwright, Jitka Čejková, Elena Fimmel, Simone Giannerini, Diego Luis Gonzalez, Greta Goracci, Clara Grácio, Jeanine Houwing-Duistermaat, Dragan Matić, Nataša Mišić, Frans A. A. Mulder, Oreste Piro

Artificial Life (2024) 30 (1): 16–27.

In the mid-20th century, two new scientific disciplines emerged forcefully: molecular biology and information-communication theory. At the beginning, cross-fertilization was so deep that the term genetic code was universally accepted for describing the meaning of triplets of mRNA (codons) as amino acids. However, today, such synergy has not taken advantage of the vertiginous advances in the two disciplines and presents more challenges than answers. These challenges not only are of great theoretical relevance but also represent unavoidable milestones for next-generation biology: from personalized genetic therapy and diagnosis to Artificial Life to the production of biologically active proteins. Moreover, the matter is intimately connected to a paradigm shift needed in theoretical biology, pioneered a long time ago, that requires combined contributions from disciplines well beyond the biological realm. The use of information as a conceptual metaphor needs to be turned into quantitative and predictive models that can be tested empirically and integrated in a unified view. Successfully achieving these tasks requires a wide multidisciplinary approach, including Artificial Life researchers, to address such an endeavour.

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Francis Heylighen, Shima Beigi, and Tomas Veloz

Systems 2024, 12(4), 111

This paper summarizes and reviews Chemical Organization Theory (COT), a formalism for the analysis of complex, self-organizing systems across multiple disciplines. Its elements are resources and reactions. A reaction maps a set of resources onto another set, thus representing an elementary process that transforms resources into new resources. Reaction networks self-organize into invariant subnetworks, called ‘organizations’, which are attractors of their dynamics. These are characterized by closure (no new resources are added) and self-maintenance (no existing resources are lost). Thus, they provide a simple model of autopoiesis: the organization persistently recreates its own components. The resilience of organizations in the face of perturbations depends on properties such as the size of their basin of attraction and the redundancy of their reaction pathways. Application domains of COT include the origin of life, systems biology, cognition, ecology, Gaia theory, sustainability, consciousness, and social systems.

Read the full article at: www.mdpi.com

AMBRA AMICO, LUCA VERGINER, GIONA CASIRAGHI, GIACOMO VACCARIO, AND FRANK SCHWEITZER
SCIENCE ADVANCES
17 Jan 2024
Vol 10, Issue 3

Supply chain disruptions may cause shortages of essential goods, affecting millions of individuals. We propose a perspective to address this problem via reroute flexibility. This is the ability to substitute and reroute products along existing pathways, hence without requiring the creation of new connections. To showcase the potential of this approach, we examine the US opioid distribution system. We reconstruct over 40 billion distribution routes and quantify the effectiveness of reroute flexibility in mitigating shortages. We demonstrate that flexibility (i) reduces the severity of shortages and (ii) delays the time until they become critical. Moreover, our findings reveal that while increased flexibility alleviates shortages, it comes at the cost of increased complexity: We demonstrate that reroute flexibility increases alternative path usage and slows down the distribution system. Our method enhances decision-makers’ ability to manage the resilience of supply chains.

Read the full article at: www.science.org

Patrick McMillen & Michael Levin 

Communications Biology volume 7, Article number: 378 (2024)

A defining feature of biology is the use of a multiscale architecture, ranging from molecular networks to cells, tissues, organs, whole bodies, and swarms. Crucially however, biology is not only nested structurally, but also functionally: each level is able to solve problems in distinct problem spaces, such as physiological, morphological, and behavioral state space. Percolating adaptive functionality from one level of competent subunits to a higher functional level of organization requires collective dynamics: multiple components must work together to achieve specific outcomes. Here we overview a number of biological examples at different scales which highlight the ability of cellular material to make decisions that implement cooperation toward specific homeodynamic endpoints, and implement collective intelligence by solving problems at the cell, tissue, and whole-organism levels. We explore the hypothesis that collective intelligence is not only the province of groups of animals, and that an important symmetry exists between the behavioral science of swarms and the competencies of cells and other biological systems at different scales. We then briefly outline the implications of this approach, and the possible impact of tools from the field of diverse intelligence for regenerative medicine and synthetic bioengineering.

Read the full article at: www.nature.com

Alan Dorin, Susan Stepney

Artificial Life (2024) 30 (1): 1–15.

The field called Artificial Life (ALife) coalesced following a workshop organized by Chris Langton in September 1987 (Langton, 1988a). That meeting drew together work that had been largely carried out from the 1950s through to the 1980s. A few years later, Langton became the founding editor of this journal, Artificial Life, which started its life with Volume 1, Issue 1_2 in the (northern) winter of 1993/1994.1 This current issue therefore begins the 30th volume and 30th year of Artificial Life. We think this is a milestone worth celebrating!
In the proceedings of that first workshop, Langton famously defined ALife as the study of “life as it could be,” of “possible life,” in contrast to biology’s study of “life as we know it to be” (on Earth). His stated aim was to derive “a truly general theoretical biology capable of making universal statements about life wherever it may be found and whatever it may be made of ” (Langton, 1988b, p. xvi).

Read the full article at: direct.mit.edu