Blai Vidiella, Antoni Guillamon, Josep Sardanyés, Victor Maull, Jordi Pla, Nuria Conde & Ricard Solé 

Nature Communications volume 12, Article number: 4415 (2021)

Complex dynamical fluctuations, from intracellular noise, brain dynamics or computer traffic display bursting dynamics consistent with a critical state between order and disorder. Living close to the critical point has adaptive advantages and it has been conjectured that evolution could select these critical states. Is this the case of living cells? A system can poise itself close to the critical point by means of the so-called self-organized criticality (SOC). In this paper we present an engineered gene network displaying SOC behaviour. This is achieved by exploiting the saturation of the proteolytic degradation machinery in E. coli cells by means of a negative feedback loop that reduces congestion. Our critical motif is built from a two-gene circuit, where SOC can be successfully implemented. The potential implications for both cellular dynamics and behaviour are discussed.

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Johan Bollen, Marijn ten Thij, Fritz Breithaupt, Alexander T. J. Barron, Lauren A. Rutter, Lorenzo Lorenzo-Luaces, and Marten Scheffer

PNAS July 27, 2021 118 (30) e2102061118;

Can entire societies become more or less depressed over time? Here, we look for the historical traces of cognitive distortions, thinking patterns that are strongly associated with internalizing disorders such as depression and anxiety, in millions of books published over the course of the last two centuries in English, Spanish, and German. We find a pronounced “hockey stick” pattern: Over the past two decades the textual analogs of cognitive distortions surged well above historical levels, including those of World War I and II, after declining or stabilizing for most of the 20th century. Our results point to the possibility that recent socioeconomic changes, new technology, and social media are associated with a surge of cognitive distortions.

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Jordan C. Rozum, Jorge Gómez Tejeda Zañudo, Xiao Gan, Dávid Deritei and Réka Albert
Science Advances  16 Jul 2021:
Vol. 7, no. 29, eabf8124
DOI: 10.1126/sciadv.abf8124

We present new applications of parity inversion and time reversal to the emergence of complex behavior from simple dynamical rules in stochastic discrete models. Our parity-based encoding of causal relationships and time-reversal construction efficiently reveal discrete analogs of stable and unstable manifolds. We demonstrate their predictive power by studying decision-making in systems biology and statistical physics models. These applications underpin a novel attractor identification algorithm implemented for Boolean networks under stochastic dynamics. Its speed enables resolving a long-standing open question of how attractor count in critical random Boolean networks scales with network size and whether the scaling matches biological observations. Via 80-fold improvement in probed network size (N = 16,384), we find the unexpectedly low scaling exponent of 0.12 ± 0.05, approximately one-tenth the analytical upper bound. We demonstrate a general principle: A system’s relationship to its time reversal and state-space inversion constrains its repertoire of emergent behaviors.

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Sheryl L. Chang, Oliver M. Cliff, Mikhail Prokopenko
As of July 2021, there is a continuing outbreak of the B.1.617.2 (Delta) variant of SARS-CoV-2 in Sydney, Australia. The outbreak is of major concern as the Delta variant is estimated to have twice the reproductive number to previous variants that circulated in Australia in 2020, which is worsened by low levels of acquired immunity in the population. Using a re-calibrated agent-based model, we explored a feasible range of non-pharmaceutical interventions, in terms of both mitigation (case isolation, home quarantine) and suppression (school closures, social distancing). Our nowcasting modelling indicated that the level of social distancing currently attained in Sydney is inadequate for the outbreak control. A counter-factual analysis suggested that if 80% of agents comply with social distancing, then at least a month is needed for the new daily cases to reduce from their peak to below ten. A small reduction in social distancing compliance to 70% lengthens this period to over two months.

Read the full article at: arxiv.org

Thayer Alshaabi, Jane L. Adams, Michael V. Arnold, Joshua R. Minot, David R. Dewhurst, Andrew J. Reagan, Christopher M. Danforth, and Peter Sheridan Dodds

Science Advances  16 Jul 2021:

Vol. 7, no. 29, eabe6534
DOI: 10.1126/sciadv.abe6534

In real time, Twitter strongly imprints world events, popular culture, and the day-to-day, recording an ever-growing compendium of language change. Vitally, and absent from many standard corpora such as books and news archives, Twitter also encodes popularity and spreading through retweets. Here, we describe Storywrangler, an ongoing curation of over 100 billion tweets containing 1 trillion 1-grams from 2008 to 2021. For each day, we break tweets into 1-, 2-, and 3-grams across 100+ languages, generating frequencies for words, hashtags, handles, numerals, symbols, and emojis. We make the dataset available through an interactive time series viewer and as downloadable time series and daily distributions. Although Storywrangler leverages Twitter data, our method of tracking dynamic changes in n-grams can be extended to any temporally evolving corpus. Illustrating the instrument’s potential, we present example use cases including social amplification, the sociotechnical dynamics of famous individuals, box office success, and social unrest.

Read the full article at: advances.sciencemag.org