ERIC NGUYEN, et al.

SCIENCE 15 Nov 2024 Vol 386, Issue 6723

Evo is a foundation model that is designed to capture two fundamental aspects of biology: the multimodality of the central dogma and the multiscale nature of evolution. The central dogma integrates DNA, RNA, and proteins with a unified code and predictable information flow, whereas evolution unifies the vastly different length scales of biological function represented by molecules, pathways, cells, and organisms. Evo learns both of these representations from the whole-genome sequences of millions of organisms to enable prediction and design tasks from the molecular to genome scale. Further development of large-scale biological sequence models like Evo, combined with advances in DNA synthesis and genome engineering, will accelerate our ability to engineer life.

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