Author: cxdig

Finding Patient Zero: Learning Contagion Source with Graph Neural Networks

Chintan Shah, Nima Dehmamy, Nicola Perra, Matteo Chinazzi, Albert-László Barabási, Alessandro Vespignani, Rose Yu

 

Locating the source of an epidemic, or patient zero (P0), can provide critical insights into the infection’s transmission course and allow efficient resource allocation. Existing methods use graph-theoretic centrality measures and expensive message-passing algorithms, requiring knowledge of the underlying dynamics and its parameters. In this paper, we revisit this problem using graph neural networks (GNNs) to learn P0. We establish a theoretical limit for the identification of P0 in a class of epidemic models. We evaluate our method against different epidemic models on both synthetic and a real-world contact network considering a disease with history and characteristics of COVID-19.

We observe that GNNs can identify P0 close to the theoretical bound on accuracy, without explicit input of dynamics or its parameters. In addition, GNN is over 100 times faster than classic methods for inference on arbitrary graph topologies. Our theoretical bound also shows that the epidemic is like a ticking clock, emphasizing the importance of early contact-tracing. We find a maximum time after which accurate recovery of the source becomes impossible, regardless of the algorithm used.

Source: arxiv.org

The impact of COVID-19 and strategies for mitigation and suppression in low- and middle-income countries

Patrick G. T. Walker, et al.

Science 12 Jun 2020:
eabc0035
DOI: 10.1126/science.abc0035

 

The ongoing COVID-19 pandemic poses a severe threat to public health worldwide. We combine data on demography, contact patterns, disease severity, and health care capacity and quality to understand its impact and inform strategies for its control. Younger populations in lower income countries may reduce overall risk but limited health system capacity coupled with closer inter-generational contact largely negates this benefit. Mitigation strategies that slow but do not interrupt transmission will still lead to COVID-19 epidemics rapidly overwhelming health systems, with substantial excess deaths in lower income countries due to the poorer health care available. Of countries that have undertaken suppression to date, lower income countries have acted earlier. However, this will need to be maintained or triggered more frequently in these settings to keep below available health capacity, with associated detrimental consequences for the wider health, well-being and economies of these countries.

Source: science.sciencemag.org

Reducing transmission of SARS-CoV-2

Kimberly A. Prather, Chia C. Wang, Robert T. Schooley

Science 26 Jun 2020:
Vol. 368, Issue 6498, pp. 1422-1424
DOI: 10.1126/science.abc6197

 

Respiratory infections occur through the transmission of virus-containing droplets (>5 to 10 µm) and aerosols (≤5 µm) exhaled from infected individuals during breathing, speaking, coughing, and sneezing. Traditional respiratory disease control measures are designed to reduce transmission by droplets produced in the sneezes and coughs of infected individuals. However, a large proportion of the spread of coronavirus disease 2019 (COVID-19) appears to be occurring through airborne transmission of aerosols produced by asymptomatic individuals during breathing and speaking (1—3). Aerosols can accumulate, remain infectious in indoor air for hours, and be easily inhaled deep into the lungs. For society to resume, measures designed to reduce aerosol transmission must be implemented, including universal masking and regular, widespread testing to identify and isolate infected asymptomatic individuals.

Source: science.sciencemag.org

Epidemics Dynamics & Control on Networks. Call for papers

Networks are ubiquitous in natural, technological and social systems. They offer a fertile framework for understanding and controlling the diffusion of ideas, rumors, and infectious diseases of plants, animals, and humans. Despite recent advances, many challenging scientific questions remain about the correct tools and their practical role in epidemics dynamics and effective strategies supporting public health decision making. The goal of this special issue is to offer a platform to the interdisciplinary community of scientists working on the diffusion process on networks and its plethora of applications. We hope for a broad range of topics to be covered, across theory, methodology, and application to empirical data with a special emphasis on epidemic spreading.

 

Important dates
Expression of interest and abstract submission: July 10, 2020
Abstract feedback notification: July 13, 2020
Paper submission deadline: September 21, 2020
Target publication: November 01, 2020

Source: appliednetsci.springeropen.com