Sara Imari Walker
One of the longest standing open problems in science is how life arises from non-living matter. If it is possible to measure this transition in the lab, then it might be possible to understand the physical mechanisms by which the emergence of life occurs, which so far have evaded scientific understanding. A significant hurdle is the lack of standards or a framework for cross comparison across different experimental contexts and planetary environments. In this essay, I review current challenges in experimental approaches to origin of life chemistry, focusing on those associated with quantifying experimental selectivity versus de novo generation of molecular complexity, and I highlight new methods using molecular assembly theory to measure molecular complexity. This metrology-centered approach can enable rigorous testing of hypotheses about the cascade of major transitions in molecular order marking the emergence of life, while potentially bridging traditional divides between metabolism-first and genetics-first scenarios. Grounding the study of life’s origins in measurable complexity has significant implications for the search for life beyond Earth, suggesting paths toward theory-driven detection of biological complexity in diverse planetary contexts. As the field moves forward, standardized measurements of molecular complexity may help unify currently disparate approaches to understanding how matter transforms to life. Much remains to be done in this exciting frontier.

Read the full article at: arxiv.org

ONERVA KORHONEN

Advances in Complex Systems Vol. 28, No. 08, 2530001 (2025)

Network analysis has become a powerful tool in various fields. However, the increasing popularity comes with potential problems. Unfamiliarity with the characteristics of the systems under investigation complicates network model construction and interpretation of analysis outcomes. While these issues require special attention in studies that apply the increasingly complex higher-order connectivity models, similar problems are associated with all, even the most simple, network models. Alongside technical issues, network scientists face a philosophical question: can the network approach discover the fundamental nature of a system, on the one hand, and produce useful information, on the other hand. In this perspective, I review the potential problems of the network approach and propose two solutions to address them: active evaluation of the potential and limitations of the network framework before applying a network model and a transition toward an interdisciplinary research practice to interpret analysis outcomes in their right context.

Read the full article at: www.worldscientific.com

Costolo, Michael

This paper introduces a constraint-limited model of combinatorial growth that examines how feasibility scales with increasing system dimensionality. The framework analyzes the balance between expanding possibility spaces and constraint structures that prune feasible configurations. The model shows that when feasible configurations grow as c^n within a combinatorial space of size 2^n, the feasible fraction collapses for constant c < 2. Sustained novelty generation therefore requires c(n) to approach the combinatorial base, producing a narrow “complexity corridor” between regimes of trivial repetition and combinatorial sparsity. The paper derives the analytic structure of this corridor and explores it through numerical simulations and visualizations. The results suggest a possible structural explanation for why complex systems may emerge only within a narrow range where combinatorial expansion and constraint relaxation operate at comparable scales.  The manuscript includes the full mathematical derivation, simulation results, and discussion of implications for complex systems.

Read the full article at: zenodo.org

How and why do complex chemical and biological systems self-organize into ordered states far from thermodynamic equilibrium? Despite advances in thermodynamics, kinetics, and information theory, a unifying principle that links organization and efficiency across scales has remained elusive. In open systems, productive-event trajectories are conditioned on starting at a source and ending at a sink. This work proposes a stochastic–dissipative least-action triad framework in which (i) a path-ensemble weighting biases trajectories by their action cost, (ii) feedback processes sharpen this distribution, and (iii) the ensemble evolves toward a least-average-action attractor, decreasing during self-organization and increasing during decay. A parametric cross-scale metric—Average Action Efficiency (AAE)—is defined, which is inversely proportional to the average action per productive event. Under reinforcing feedback, identities derived from the exponential-family path measure show that the average action decreases and AAE rises monotonically. In future extensions, this formulation could help bridge quantum, classical, and biological regimes while remaining computationally tractable, because its empirical version relies on aggregate energetic and timing data rather than enumerating individual trajectories. AAE reaches a local maximum at a non-equilibrium steady state under fixed operational context, consistent with the present formulation, and connections to thermodynamic and informational measures are made. A companion article (Part II) details empirical estimation strategies and applications (Georgiev, 2025a).

Georgi Yordanov Georgiev

BioSystems

Volume 262, April 2026, 105647

Read the full article at: www.sciencedirect.com

See Also: Part II: Empirical estimation, Average Action Efficiency, and applications to ATP synthase

Junhua Yuan 
Nature Physics (2026)

Spontaneous switching between active and inactive states in bacterial chemosensory arrays is shown to operate near a critical point. Through biologically controlled disorder, cells balance high signal gain with fast response.

Read the full article at: www.nature.com