Mitigating climate change effects involves strategic decisions by individuals that may choose to limit their emissions at a cost. Everyone shares the ensuing benefits and thereby individuals can free ride on the effort of others, which may lead to the tragedy of the commons. For this reason, climate action can be conveniently formulated in terms of Public Goods Dilemmas often assuming that a minimum collective effort is required to ensure any benefit, and that decision-making may be contingent on the risk associated with future losses. Here we investigate the impact of reward and punishment in this type of collective endeavors — coined as collective-risk dilemmas — by means of a dynamic, evolutionary approach. We show that rewards (positive incentives) are essential to initiate cooperation, mostly when the perception of risk is low. On the other hand, we find that sanctions (negative incentives) are instrumental to maintain cooperation. Altogether, our results are gratifying, given the a-priori limitations of effectively implementing sanctions in international agreements. Finally, we show that whenever collective action is most challenging to succeed, the best results are obtained when both rewards and sanctions are synergistically combined into a single policy.

 

Reward and punishment in climate change dilemmas
António R. Góis, Fernando P. Santos, Jorge M. Pacheco & Francisco C. Santos 
Scientific Reports volume 9, Article number: 16193 (2019)

Source: www.nature.com

Biological self-organisation can be regarded as a process of spontaneous pattern formation; namely, the emergence of structures that distinguish themselves from their environment. This process can occur at nested spatial scales: from the microscopic (e.g., the emergence of cells) to the macroscopic (e.g. the emergence of organisms). In this paper, we pursue the idea that Markov blankets – that separate the internal states of a structure from external states – can self-assemble at successively higher levels of organisation. Using simulations, based on the principle of variational free energy minimisation, we show that hierarchical self-organisation emerges when the microscopic elements of an ensemble have prior (e.g., genetic) beliefs that they participate in a macroscopic Markov blanket: i.e., they can only influence – or be influenced by – a subset of other elements. Furthermore, the emergent structures look very much like those found in nature (e.g., cells or organelles), when influences are mediated by short range signalling. These simulations are offered as a proof of concept that hierarchical self-organisation of Markov blankets (into Markov blankets) can explain the self-evidencing, autopoietic behaviour of biological systems.

 

On Markov blankets and hierarchical self-organisation
Ensor Rafael Palacios, Adeel Razi, Thomas Parr, Michael Kirchhoff, Karl Friston

Journal of Theoretical Biology

Source: www.sciencedirect.com

The introduction of RNA velocity in single cells has opened up new ways of studying cellular differentiation. The originally proposed framework obtains velocities as the deviation of the observed ratio of spliced and unspliced mRNA from an inferred steady state. Errors in velocity estimates arise if the central assumptions of a common splicing rate and the observation of the full splicing dynamics with steady-state mRNA levels are violated. With scVelo (https://scvelo.org), we address these restrictions by solving the full transcriptional dynamics of splicing kinetics using a likelihood-based dynamical model. This generalizes RNA velocity to a wide variety of systems comprising transient cell states, which are common in development and in response to perturbations. We infer gene-specific rates of transcription, splicing and degradation, and recover the latent time of the underlying cellular processes. This latent time represents the cell’s internal clock and is based only on its transcriptional dynamics. Moreover, scVelo allows us to identify regimes of regulatory changes such as stages of cell fate commitment and, therein, systematically detects putative driver genes. We demonstrate that scVelo enables disentangling heterogeneous subpopulation kinetics with unprecedented resolution in hippocampal dentate gyrus neurogenesis and pancreatic endocrinogenesis. We anticipate that scVelo will greatly facilitate the study of lineage decisions, gene regulation, and pathway activity identification.

 

Generalizing RNA velocity to transient cell states through dynamical modeling
Volker Bergen, Marius Lange, Stefan Peidli, F. Alexander Wolf, Fabian J. Theis

Source: www.biorxiv.org

I briefly survey several fascinating topics in networks and nonlinearity. I highlight a few methods and ideas, including several of personal interest, that I anticipate to be especially important during the next several years. These topics include temporal networks (in which the entities and/or their interactions change in time), stochastic and deterministic dynamical processes on networks, adaptive networks (in which a dynamical process on a network is coupled to dynamics of network structure), and network structure and dynamics that include "higher-order" interactions (which involve three or more entities in a network). I draw examples from a variety of scenarios, including contagion dynamics, opinion models, waves, and coupled oscillators.

 

Nonlinearity + Networks: A 2020 Vision
Mason A. Porter

Source: arxiv.org

Chaos, machine, or evolving complexity? The butterfly effect suggests a world in chaos—with linkages so random or nuanced that just to measure or pre-state them is virtually impossible. To predict how they will interact is even less feasible. Thanks to “adjacent possibles” and the contradictory impulses of human behavior, much of our world appears to move in random spasms. Every new technology and policy outcome creates opportunities to push society in new and often unforeseen directions, driven by human agents who may introduce crucial but unpredictable goals, strategies, and actions. Against this view, complexity science seeks to identify patterns in interactive relationships. Many patterns can be plotted and, in some cases, foreseen. A comparison of political entities across the globe points to certain factors conducing to societal fitness. Analysis of states that have declined in fitness suggests why their strengths turned to weaknesses. A survey of societies that were relatively democratic points to several factors that contributed to their acquiring authoritarian regimes. Scientists and scholars can unveil some elements of order but should strive to do so without hubris. Wise policymakers will strive to channel both the “actuals” and “adjacent possibles” that then arise toward constructive futures.

 

NETSOL: New Trends in Social and Liberal Sciences

Year: 2019 / Volume : 2 / Area: Interdisciplinary Studies

Walter C. Clemens and Stuart A. Kauffman
Is the World Chaos, a Machine, or Evolving Complexity? How Well Can We Understand Life and World Affairs? pp.24-43.

Source: www.netsoljournal.net