On this episode of BeyondPhrenology, I speak with Dr. Gabriele Scheler (Carl Correns Foundation for Mathematical Biology) about the state of AI and neuroscience—past the hype, and closer to their limits.

We begin by revisiting what AI once meant: symbolic systems, logic, early neural networks, and the long-standing divide between learning and reasoning. Against that backdrop, we examine the current moment, where large language models dominate the conversation but remain, in many ways, underwhelming relative to the broader ambitions of artificial intelligence.

The discussion then turns to neuroscience, where despite decades of experimental progress, a central problem remains unresolved: the absence of integrated, functional models of cognition. We explore the consequences of a synapse-centric view, the limits of current theoretical approaches, and why accumulating more data—without perspective—fails to move the field forward. Along the way, we touch on issues that rarely make it into official narratives: the role of funding structures, the drift toward mediocrity, and the persistence of poorly framed questions.

From there, we consider an alternative direction. Dr. Scheler outlines a neuron-centric, function-driven approach to modeling the brain—one that emphasizes modularity, one-shot learning, internal inference, and decision-making as a unifying principle across cognition and emotion. Framed through evolution, this perspective highlights how biological systems bridge scales of structure and function in ways current models largely fail to capture.

The episode closes by reflecting on what this means for the future: not just for AI, but for science itself—how research cultures shift, why fascination alone is not enough, and what it would take to build models that are not just complex, but actually explanatory.
Watch at: www.youtube.com